     |
|
| Previous Nomenclature | Nuclear rim, nuclear envelope/membrane. |
| Description | Homogeneous staining of the nucleus with greater intensity of the outer rim and no staining of the metaphase and anaphase chromatin. Accentuation of fluorescence where adjacent cells touch each other may be observed. |
| Antigen Association | Lamins A,B,C, lamin-associated proteins, or lamin B receptor (LBR). |
|
Clinical Relevance
First level information About Clinical Relevance & List of Abbreviations |
|
▶ The AC-11 pattern is infrequently found in routine autoantibody testing and has been described in autoimmune-cytopenia, autoimmune liver diseases, linear scleroderma, anti-phospholipid syndrome, systemic autoimmune rheumatic diseases, and in individuals with no apparent autoimmune disease; current information on clinical associations is based mainly on case reports and small cohorts [1-5]. ▶ In general clinical laboratories, the AC-11 pattern is more frequently observed than the AC-12 pattern, the other nuclear envelope pattern ▶ Antigens recognized include lamins (A, B, C) and LAP-2; specific immunoassays for these autoantibodies are currently not commercially available [1-4]. |
| Second level information |
|
▶ LBR antibodies have been described in PBC [6]. |
| References |
|
1. Coppo P, Clauvel JP, Bengoufa D, Fuentes V, Gouilleux-Gruart V, Courvalin JC, Lassoued K. Autoimmune cytopenias associated with autoantibodies to nuclear envelope polypeptides. Am J Hematol. 2004;77:241-9 2. Konstantinov K, Foisner R, Byrd D, Liu FT, Tsai WM, Wiik A, Gerace L. Integral membrane proteins associated with the nuclear lamina are novel autoimmune antigens of the nuclear envelope. Clin Immunol Immunopathol. 1995;74:89-99 3. Reeves WH, Chaudhary N, Salerno A, Blobel G. Lamin B autoantibodies in sera of certain patients with systemic lupus erythematosus. J Exp Med. 1987;165:750-62 4. Senecal JL, Raymond Y. Autoantibodies to DNA, lamins, and pore complex proteins produce distinct peripheral fluorescent antinuclear antibody patterns on the HEp-2 substrate. Arthritis Rheum. 1991;34:249-51 5. Zhang W, Zhang C, Chen P, Yang C, Gan X, Hussain M, Xun Y, Tian Y, et al. Circulation autoantibody against Lamin A/C in patients with Sjogren's syndrome. Oncotarget. 2016;7:80252-61 |