ANA Patterns

Welcome to ANApatterns.org, the official website for the International Consensus on Antinuclear Antibody (ANA) Patterns (ICAP). ICAP was initiated as a workshop aiming to thoroughly discuss and to promote consensus regarding the richness in nuances of morphological patterns observed in the indirect immunofluorescence assay on HEp-2 cells. The ICAP initiative was implemented at the 12th International Workshop on Autoantibodies and Autoimmunity (IWAA) by members of the Autoantibody Standardization Committee (ASC), a subcommittee of the International Union of Immunological Societies (IUIS) Quality Assessment and Standardization Committee and affiliated with the Centers for Diseases Control and Prevention (CDC). The ICAP committee is operating as an ASC sub-committee.

Citation for this work: E.K.L. Chan, J. Damoiseaux, O.G. Carballo, K. Conrad, W. de Melo Cruvinel, P.L.C. Francescantonio, M.J. Fritzler, I. Garcia-De La Torre, M. Herold, T. Mimori, M. Satoh, C.A. von Mühlen, and L.E.C. Andrade. Report of the First International Consensus on Standardized Nomenclature of Antinuclear Antibody HEp-2 Cell Patterns (ICAP) 2014-2015 (Front. Immunol. 2015, Aug 20;6:412).

Representative images, based on pixel dimension, resolution, and size, were submitted online by ICAP members. For each pattern, between 2 to >10 images were submitted. Most patterns had average 5 to 8 images. More than ten ICAP members voted for the best three images representing each pattern and the top two images for each pattern are displayed on this web site. (For an introduction of the website with some graphic images, click here.)

Announcements and Updates
Thu, 18 Feb 21	The complete translation draft to Korean goes online.
Fri, 24 Jul 20	ICAP training Module 1 available. Our first ICAP training module is now online. To get to it, you have to register, login, and follow the training icon on the top menu. Read user comments for training Module 1: User's comments for training Module 1 8/14/2020 In my lab we are frequent users of the ICAP website and I was delighted to receive your email, because training material on IFA in general is VERY scarce - and developed by ICAP, it was bound to be good. I've been through the first training module now and it's brilliant! Kind regards and thank you for your efforts, Trine-Line Korsholm Aarhus University Hospital, Denmark 8/17/2020 Congratulation to this excellent training module. learned something new with the test. You all did a great job which will be a great enrichment for ANApatterns.org. Nice regards, Manfred Herold Medical University of Innsbruck, Austria 9/25/2020 Thank you!! Wonderful course! This First training is very practice with hot topics in the area. Excellent exercise. Good basic overview of HEp-2 procedure. It is a very helpful course for new and experienced laboratory technicians in the processing of ANA. It gives a full example of procedure and some valuable tips for an optimal ANA interpretation. I enjoyed the training. Excellent training module. Very lucid and helpful. Thank you all for this very important initiative. It certainly will help to improve the performance of our HEp-2 cell assays and to capacitate our analysts. If this could be available in other languages it would help to use for all our collaborators. Stay safe! Perhaps I was expecting microscopic training particularly in expert level. what I found was a thoroughly explained technique very good beginning! Thank you all for your dedication, excellent educational web site. Very detailed and good for beginners, would be nice to have more questions for pattern recognition including cytoplasmic patterns and mixed patterns. Thanks for all your hard work.
Tue, 07 Jan 20	Information from the ICAP clinical relevance publication (Damoiseaux et al, Ann Rheum Dis 78: 879-89, 2019) is now incorporated to the website.
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Submit your question to ICAP. Only confirmed users can submit a question. If you are not registered, click here to start. Submitted questions will be routed to ICAP Coordinators Edward K. L. Chan (echan@ufl.edu) and Luis E. C. Andrade (luis.andrade@unifesp.br). Simple questions will be answered within 24 hours. Complex questions will be routed to several ICAP members either for a consensus or to provide different viewpoints and it may take 72 hours to 2 weeks for an answer. click here